Bruton's tyrosine kinase and RAC1 promote cell survival in MLL-rearranged acute myeloid leukemia

Leukemia. 2018 Mar;32(3):846-849. doi: 10.1038/leu.2017.324. Epub 2017 Nov 7.

Authors

S C Nimmagadda¹, S Frey¹, B Edelmann¹, C Hellmich², L Zaitseva², G M König³, E Kostenis³, K M Bowles^{2

4}, T Fischer¹

Affiliations

¹ Department of Hematology and Oncology, Medical Center, Otto-von-Guericke University, Magdeburg, Germany.
² Department of Molecular Haematology, Norwich Medical School, The University of East Anglia, Norwich Research Park, Norwich, UK.
³ Institute of Pharmaceutical Biology, University of Bonn, Bonn, Germany.
⁴ Department of Haematology, Norfolk and Norwich University Hospitals NHS Trust, Colney Lane, Norwich, UK.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Agammaglobulinaemia Tyrosine Kinase / metabolism*
Cell Line
Cell Survival / genetics
Gene Rearrangement*
Humans
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / metabolism*
Myeloid-Lymphoid Leukemia Protein / genetics*
rac1 GTP-Binding Protein / metabolism*

Substances

Myeloid-Lymphoid Leukemia Protein
Agammaglobulinaemia Tyrosine Kinase
rac1 GTP-Binding Protein