Spared Nerve Injury as a Long-Lasting Model of Neuropathic Pain

Serena Boccella; Francesca Guida; Enza Palazzo; Ida Marabese; Vito de Novellis; Sabatino Maione; Livio Luongo

doi:10.1007/978-1-4939-7571-6_28

Spared Nerve Injury as a Long-Lasting Model of Neuropathic Pain

Methods Mol Biol. 2018:1727:373-378. doi: 10.1007/978-1-4939-7571-6_28.

Authors

Serena Boccella¹, Francesca Guida¹, Enza Palazzo¹, Ida Marabese¹, Vito de Novellis¹, Sabatino Maione¹, Livio Luongo²

Affiliations

¹ Division of Pharmacology, Department of Experimental Medicine, University of Campania "L. Vanvitelli", Naples, Italy.
² Division of Pharmacology, Department of Experimental Medicine, University of Campania "L. Vanvitelli", Naples, Italy. livio.luongo@gmail.com.

PMID: 29222796
DOI: 10.1007/978-1-4939-7571-6_28

Abstract

This chapter describes surgical procedures for the induction of neuropathic pain using an animal model (rat or mouse) of spared nerve injury. In addition to technical details of the surgical technique, details of anesthesia and perioperative care are also included.

Keywords: Mouse; Neuropathic pain; Pain behavior; Rat; Spared nerve injury model; Surgery.

MeSH terms

Animals
Disease Models, Animal*
Mice
Mice, Inbred C57BL
Neuralgia / pathology*
Pain Threshold
Peripheral Nerve Injuries / complications*
Peripheral Nerve Injuries / genetics
Peripheral Nerve Injuries / pathology
Rats
Rats, Sprague-Dawley
Sural Nerve / surgery*