Custom-made, antibiotic-loaded, acrylic cement spacers using a dental silicone template for treatment of infected hip prostheses

Eur J Orthop Surg Traumatol. 2018 May;28(4):615-620. doi: 10.1007/s00590-017-2117-3. Epub 2018 Jan 13.

Abstract

Purpose: Antibiotic-loaded acrylic cement (ALAC) spacers are useful for treatment of infected prostheses in the course of a two-stage revision. Spacers are handmade or are made using a commercial template, with reportedly good treatment outcomes. This study aimed to confirm the usefulness of custom-made ALAC spacers shaped like bipolar hip prostheses using a dental silicone template for treatment of infected hip prostheses, and described their manufacture.

Methods: This study evaluated 10 patients who underwent two-stage revision for treatment of infected hip prostheses. Custom-made ALAC spacers were used in all patients. Templates were made with dental silicone. We investigated the following in treatment of the infected hip prostheses: bacterial pathogens; antibiotic-cement mixtures; waiting time to revision; dislocation, breakage, and migration of custom-made ALAC spacers; current hip status; progress during follow-up; presence or absence of recurrence; and walking ability.

Results: Dislocation, breakage, and migration were not observed in custom-made ALAC spacers. All patients recovered after two-stage revision without additional surgery and showed no recurrence during the follow-up period.

Conclusion: Custom-made ALAC spacers shaped like bipolar hip prostheses using a template made of dental silicone may be useful for treatment of infected hip prostheses.

Keywords: Antibiotic-loaded acrylic cement; Custom-made; Hip joint; Infected prosthesis; Two-stage revision.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Anti-Bacterial Agents / administration & dosage*
  • Arthroplasty, Replacement, Hip
  • Bone Cements / therapeutic use*
  • Dibekacin / administration & dosage
  • Equipment Design
  • Female
  • Hip Prosthesis
  • Humans
  • Male
  • Methicillin Resistance / drug effects
  • Middle Aged
  • Polymethyl Methacrylate / therapeutic use*
  • Prosthesis-Related Infections / drug therapy*
  • Reoperation
  • Silicone Elastomers
  • Staphylococcal Infections / drug therapy
  • Surgical Instruments
  • Time-to-Treatment
  • Treatment Outcome
  • Vancomycin / administration & dosage

Substances

  • Anti-Bacterial Agents
  • Bone Cements
  • Silicone Elastomers
  • Dibekacin
  • Vancomycin
  • Polymethyl Methacrylate