Systemic multilineage engraftment in mice after in utero transplantation with human hematopoietic stem cells

Blood Adv. 2018 Jan 5;2(1):69-74. doi: 10.1182/bloodadvances.2017011585. eCollection 2018 Jan 9.

Abstract

IUHCT of human cord blood-derived CD34+ cells into fetal NSG mice results in systemic multilineage engraftment with human cells.Preconditioning with in utero injection of an anti-c-Kit receptor antibody (ACK2) results in an improved rate of engraftment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies / administration & dosage
  • Antibodies / pharmacology
  • Cell Differentiation
  • Cell Lineage*
  • Chimerism
  • Fetal Blood / transplantation
  • Fetal Diseases / therapy*
  • Graft Survival* / drug effects
  • Hematopoietic Stem Cell Transplantation / methods*
  • Humans
  • Mice
  • Mice, SCID
  • Models, Animal
  • Proto-Oncogene Proteins c-kit / immunology
  • Transplantation, Heterologous / methods*

Substances

  • Antibodies
  • Proto-Oncogene Proteins c-kit