Abstract
Photopharmaceuticals can, in principle, be created by linking photoswitchable moieties to bioactive molecules. However, a general strategy for converting a therapeutic agent into its photoswitchable version is not currently available. Herein we propose a generalizable, modular approach for obtaining light controllable bioactive agents by modifying the scaffold of a protein affinity reagent using an azobenzene photoswitch.
MeSH terms
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Azo Compounds / chemistry
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Azo Compounds / radiation effects
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Chymases / antagonists & inhibitors
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Cross-Linking Reagents / chemistry
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Cross-Linking Reagents / radiation effects
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Humans
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Peptide Fragments / chemistry*
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Peptide Fragments / radiation effects
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Photoaffinity Labels / chemistry*
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Photoaffinity Labels / radiation effects
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Protein Folding / drug effects
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Proto-Oncogene Proteins c-fyn / chemistry*
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Proto-Oncogene Proteins c-fyn / radiation effects
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Sulfanilic Acids / chemistry
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Sulfanilic Acids / radiation effects
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Ultraviolet Rays
Substances
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3,3'-bis(sulfonato)-4,4'-bis(chloroacetamide)azobenzene
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Azo Compounds
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Cross-Linking Reagents
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Peptide Fragments
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Photoaffinity Labels
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Sulfanilic Acids
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FYN protein, human
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Proto-Oncogene Proteins c-fyn
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Chymases