Heavy Water Shedding Light on Antigen-Specific T Cell Responses

Liv Eidsmo; Carmen Gerlach

doi:10.1016/j.it.2018.01.003

Heavy Water Shedding Light on Antigen-Specific T Cell Responses

Trends Immunol. 2018 Mar;39(3):170-172. doi: 10.1016/j.it.2018.01.003. Epub 2018 Jan 24.

Authors

Liv Eidsmo¹, Carmen Gerlach²

Affiliations

¹ Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, 171 76 Stockholm, Sweden; Department of Dermatology, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden.
² Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, 171 76 Stockholm, Sweden; Department of Dermatology, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden. Electronic address: carmen.gerlach@ki.se.

PMID: 29396015
DOI: 10.1016/j.it.2018.01.003

Abstract

CD8 T cells are crucial for long-term immunity. Nevertheless, the in vivo differentiation of human naïve CD8 T cells into effector and memory populations remains ill-defined. A recent study assesses the in vivo turnover of human antigen-specific CD8 T cells and suggests that long-lived memory cells arise from effector cells.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Antigens
CD8-Positive T-Lymphocytes / cytology
Cell Differentiation / immunology
Deuterium Oxide*
Humans
Immunologic Memory*

Substances

Antigens
Deuterium Oxide