High PIM1 expression is a biomarker of T-cell acute lymphoblastic leukemia with JAK/STAT activation or t(6;7)(p21;q34)/TRB@-PIM1 rearrangement

Leukemia. 2018 Aug;32(8):1807-1810. doi: 10.1038/s41375-018-0031-2. Epub 2018 Feb 2.

Affiliations

¹ Hematology and Bone Marrow Transplantation Unit, CREO, University of Perugia, Perugia, Italy.
² Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy.
³ Hematology and Bone Marrow Transplantation Unit, University of Parma, Parma, Italy.
⁴ Hematology and Bone Marrow Transplantation Unit, CREO, University of Perugia, Perugia, Italy. cristina.mecucci@unipg.it.

PMID: 29479063
DOI: 10.1038/s41375-018-0031-2

No abstract available

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism
Chromosomes, Human, Pair 7
Chromosomes, Human, Pair 9
Female
Gene Expression Regulation, Neoplastic
Gene Rearrangement*
Humans
Janus Kinase 1 / genetics
Janus Kinase 1 / metabolism*
Male
Middle Aged
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology
Prognosis
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism
Proto-Oncogene Proteins c-pim-1 / genetics*
Proto-Oncogene Proteins c-pim-1 / metabolism*
STAT Transcription Factors / genetics
STAT Transcription Factors / metabolism*
Translocation, Genetic*
Young Adult

Substances

Biomarkers, Tumor
STAT Transcription Factors
JAK1 protein, human
Janus Kinase 1
PIM1 protein, human
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins c-pim-1