Chemotherapy-Colchicine Interaction in a Child with Familial Mediterranean Fever and Hodgkin Lymphoma

Karin P S Langenberg-Ververgaert; Ronald M Laxer; Angela S Punnett; L Lee Dupuis; Yaron Finkelstein; Oussama Abla

doi:10.4084/MJHID.2018.019

Chemotherapy-Colchicine Interaction in a Child with Familial Mediterranean Fever and Hodgkin Lymphoma

Mediterr J Hematol Infect Dis. 2018 Mar 1;10(1):e2018019. doi: 10.4084/MJHID.2018.019. eCollection 2018.

Authors

Karin P S Langenberg-Ververgaert¹, Ronald M Laxer², Angela S Punnett¹, L Lee Dupuis^{3

4

5}, Yaron Finkelstein⁶, Oussama Abla¹

Affiliations

¹ Division of Hematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
² Division of Rheumatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
³ Department of Pharmacy, The Hospital for Sick Children, Toronto, Canada.
⁴ Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.
⁵ Research Institute, The Hospital for Sick Children, Toronto, Canada.
⁶ The Hospital for Sick Children, University of Toronto, Toronto, Canada.

Abstract

Familial Mediterranean fever (FMF) has been associated with hematological malignancies but has not been reported in association with Hodgkin lymphoma (HL). We hereby describe the first pediatric patient with FMF and stage IIA nodular sclerosis HL. She was treated with prednisone, doxorubicin, vincristine and etoposide (OEPA) being on therapy with colchicine. However, she suffered more than expected treatment-related toxicity attributed either to chemotherapy (severe neutropenia) or colchicine (Abdominal pains and diarrhoea). Colchicine had to be discontinued. In the absence of colchicine, she tolerated very well the second cycle of chemotherapy. Currently, she is in remission at 17 months after her HL diagnosis, and her FMF is under control with colchicine without any signs of toxicity.

Keywords: Colchicine toxicity; Drugs interaction; Familial Mediterranean fever; Hodgkin lymphoma.

Publication types

Case Reports