Abstract
We report solid-state Nuclear Magnetic Resonance (ssNMR) studies on amyloid-like protein complexes formed by DIX domains that mediate key protein interactions in the Wnt signalling pathway. Our results provide insight into the 3D fold of the self-associated Axin-DIX domain and identify a potential lipid cofactor.
MeSH terms
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Amyloid / chemistry*
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Axin Protein / chemistry*
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Axin Protein / metabolism
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Binding Sites
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Humans
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Magnetic Resonance Spectroscopy
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Peptide Fragments / chemistry*
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Peptide Fragments / metabolism
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Phosphatidylethanolamines / chemistry
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Phosphatidylethanolamines / metabolism
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Protein Binding
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Protein Domains
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Wnt Signaling Pathway*
Substances
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Amyloid
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Axin Protein
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Peptide Fragments
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Phosphatidylethanolamines