IL-33 Deals with the Gray Matter

Charlène Delmas; Elise Dalmas

doi:10.1016/j.immuni.2018.03.005

IL-33 Deals with the Gray Matter

Immunity. 2018 Mar 20;48(3):484-486. doi: 10.1016/j.immuni.2018.03.005.

Authors

Charlène Delmas¹, Elise Dalmas²

Affiliations

¹ Institut National de la Santé et de la Recherche Médicale (INSERM), Cordeliers Research Center, Paris, France; Sorbonne Paris Cité, Paris, France; Paris Diderot University, Paris, France.
² Institut National de la Santé et de la Recherche Médicale (INSERM), Cordeliers Research Center, Paris, France; Sorbonne Paris Cité, Paris, France; Paris Diderot University, Paris, France. Electronic address: edalmas@hotmail.fr.

PMID: 29562200
DOI: 10.1016/j.immuni.2018.03.005

Abstract

The central nervous system undergoes extensive postnatal synapse remodeling that is critical for the formation of mature neural circuits. In a recent issue of Science, Vainchtein et al. (2018) describe an additional role for astrocyte-derived interleukin-33 (IL-33) in promoting synapse refinement by microglia in the developing brain.

Publication types

Letter

MeSH terms

Animals
Astrocytes / metabolism
Brain / immunology
Brain / metabolism
Gray Matter / immunology
Gray Matter / metabolism*
Humans
Interleukin-33 / genetics*
Interleukin-33 / metabolism*
Microglia / immunology
Microglia / metabolism
Neurogenesis
Synapses / metabolism

Substances

Interleukin-33