Clinical Study Designs and Sources of Error in Medical Research

Aalok K Kacha; Sarah L Nizamuddin; Junaid Nizamuddin; Harish Ramakrishna; Sajid S Shahul

doi:10.1053/j.jvca.2018.02.009

Clinical Study Designs and Sources of Error in Medical Research

J Cardiothorac Vasc Anesth. 2018 Dec;32(6):2789-2801. doi: 10.1053/j.jvca.2018.02.009. Epub 2018 Feb 7.

Authors

Aalok K Kacha¹, Sarah L Nizamuddin², Junaid Nizamuddin¹, Harish Ramakrishna³, Sajid S Shahul⁴

Affiliations

¹ Section of Critical Care Medicine, Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL.
² Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL.
³ Division of Cardiovascular and Thoracic Anesthesiology, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Phoenix, AZ.
⁴ Section of Critical Care Medicine, Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL. Electronic address: sajid.shahul@gmail.com.

PMID: 29571641
DOI: 10.1053/j.jvca.2018.02.009

No abstract available

Keywords: Bayesian statistics; bias; clinical research; data reporting; error; evidence-based medicine; group sequential design; meta-analysis; methodology; study design; systematic review; trial design; trial sequential analysis.

Publication types

Review

MeSH terms

Biomedical Research / methods*
Biomedical Research / standards
Evidence-Based Medicine / methods*
Evidence-Based Medicine / standards
Humans
Randomized Controlled Trials as Topic / methods*
Randomized Controlled Trials as Topic / standards
Research Design* / standards