FLAX OIL FROM TRANSGENIC LINUM USITATISSIMUM SELECTIVELY INHIBITS IN VITRO PROLIFERATION OF HUMAN CANCER CELL LINES

Acta Pol Pharm. 2017 Mar;74(2):653-659.

Abstract

Emulsions made of oils from transgenic flaxseeds significantly decreased in vitro proliferation of six tested human cancer cell lines in 48-h cultures, as assessed with the standard sulforhodamine assay. However, the emulsions also increased proliferation rate of normal human dermal fibroblasts and, to a lower extend, of keratinocytes. Both inhibition of in vitro proliferation of human cancer cell lines and stimulation of proliferation of normal dermal fibroblasts and keratinocytes were especially strong with the emulsion type B and with emulsion type M. Oils from seeds of transgenic flax type B and M should be considered as valuable adjunct to standard cytostatic therapy of human cancers and also could be applied to improve the treatment of skin lesions in wound healing.

MeSH terms

  • A549 Cells
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Proliferation / drug effects*
  • Dose-Response Relationship, Drug
  • Fibroblasts / drug effects
  • Flax / genetics*
  • Humans
  • Keratinocytes / drug effects
  • MCF-7 Cells
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Phytotherapy
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Oils / isolation & purification
  • Plant Oils / pharmacology*
  • Plants, Genetically Modified / genetics*
  • Plants, Medicinal
  • Seeds
  • Wound Healing / drug effects

Substances

  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • Plant Oils