Lumbar arthrodesis infection by multi-resistant Klebsiella pneumoniae, successfully treated with implant retention and ceftazidime/avibactam

Rev Esp Cir Ortop Traumatol (Engl Ed). 2018 Nov-Dec;62(6):471-473. doi: 10.1016/j.recot.2018.02.002. Epub 2018 Apr 7.
[Article in English, Spanish]

Abstract

There are increasingly more patients with prosthetic implants (orthopaedic prostheses, lumbar instruments, osteosynthesis material). In the last decade, infections caused by carbapenem resistant Enterobacteriaceae have increased (bacteriaemia, abscesses, urinary tract infections...) with great difficulty in treatment and important associated comorbidity. We present the first case of infection of a lumbar instrumentation by Klebsiella pneumoniae producing carbapenemase D, OXA-48 type, and successfully treated.

Keywords: Arthrodesis; Artrodesis; Carbapenemasa; Carbapenemase; Ceftazidima/avibactam; Ceftazidime/avibactam.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Arthrodesis*
  • Azabicyclo Compounds / therapeutic use*
  • Ceftazidime / therapeutic use*
  • Drug Combinations
  • Drug Resistance, Multiple, Bacterial
  • Female
  • Humans
  • Klebsiella Infections / diagnosis
  • Klebsiella Infections / drug therapy*
  • Klebsiella Infections / etiology
  • Klebsiella pneumoniae* / drug effects
  • Klebsiella pneumoniae* / isolation & purification
  • Lumbar Vertebrae / microbiology
  • Lumbar Vertebrae / surgery*
  • Surgical Wound Infection / diagnosis
  • Surgical Wound Infection / drug therapy*

Substances

  • Anti-Bacterial Agents
  • Azabicyclo Compounds
  • Drug Combinations
  • avibactam, ceftazidime drug combination
  • Ceftazidime