Radiolabeled polyoxometalate clusters: Kidney dysfunction evaluation and tumor diagnosis by positron emission tomography imaging

Dalong Ni; Dawei Jiang; Hyung-Jun Im; Hector F Valdovinos; Bo Yu; Shreya Goel; Todd E Barnhart; Peng Huang; Weibo Cai

doi:10.1016/j.biomaterials.2018.04.019

Radiolabeled polyoxometalate clusters: Kidney dysfunction evaluation and tumor diagnosis by positron emission tomography imaging

Biomaterials. 2018 Jul:171:144-152. doi: 10.1016/j.biomaterials.2018.04.019. Epub 2018 Apr 12.

Authors

Dalong Ni¹, Dawei Jiang², Hyung-Jun Im³, Hector F Valdovinos⁴, Bo Yu¹, Shreya Goel⁵, Todd E Barnhart⁴, Peng Huang², Weibo Cai⁶

Affiliations

¹ Department of Radiology, University of Wisconsin-Madison, Wisconsin, USA.
² Department of Radiology, University of Wisconsin-Madison, Wisconsin, USA; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen, China.
³ Department of Radiology, University of Wisconsin-Madison, Wisconsin, USA; Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.
⁴ Department of Radiology, University of Wisconsin-Madison, Wisconsin, USA; Department of Medical Physics, University of Wisconsin-Madison, Wisconsin, USA.
⁵ Materials Science Program, University of Wisconsin-Madison, Wisconsin, USA.
⁶ Department of Radiology, University of Wisconsin-Madison, Wisconsin, USA; Materials Science Program, University of Wisconsin-Madison, Wisconsin, USA; Department of Medical Physics, University of Wisconsin-Madison, Wisconsin, USA; University of Wisconsin Carbone Cancer Center, Wisconsin, USA. Electronic address: wcai@uwhealth.org.

Abstract

Radiolabeled nanoprobes for positron emission tomography (PET) imaging has received special attention over the past decade, allowing for sensitive, non-invasive, and quantitative detection of different diseases. The rapidly renal clearable nanomaterials normally suffer from a low accumulation in the tumor through the enhanced permeability and retention (EPR) effect due to the rapidly reduced concentration in the blood circulation after renal clearance. It is highly important to design radiolabeled nanomaterials which can meet the balance between the rapid renal clearance and strong EPR effect within a suitable timescale. Herein, renal clearable polyoxometalate (POM) clusters of ultra-small size (∼1 nm in diameter) were readily radiolabeled with the oxophilic ⁸⁹Zr to obtain ⁸⁹Zr-POM clusters, which may allow for efficient staging of kidney dysfunction in a murine model of unilateral ureteral obstruction (UUO). Furthermore, the as-synthesized clusters can accumulate in the tumor through EPR effect and self-assemble into larger nanostructures in the acidic tumor microenvironment for enhanced tumor accumulation, offering an excellent balance between renal clearance and EPR effect.

Keywords: EPR effect; Kidney dysfunction; Nanomedicine; Positron emission tomography; Tumor diagnosis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Kidney / diagnostic imaging*
Kidney / physiopathology*
Kidney Neoplasms / diagnosis*
Kidney Neoplasms / diagnostic imaging*
Kidney Neoplasms / physiopathology
Mice
Positron-Emission Tomography*
Radiopharmaceuticals / chemistry*
Tungsten Compounds / chemistry*
Ureteral Obstruction / diagnostic imaging
Zirconium / administration & dosage
Zirconium / chemistry

Substances

Radiopharmaceuticals
Tungsten Compounds
polyoxometalate I
Zirconium

Abstract

Publication types

MeSH terms

Substances

Grants and funding