The Lysosome, Elixir of Neural Stem Cell Youth

Milos S Simic; Andrew Dillin

doi:10.1016/j.stem.2018.04.017

The Lysosome, Elixir of Neural Stem Cell Youth

Cell Stem Cell. 2018 May 3;22(5):619-620. doi: 10.1016/j.stem.2018.04.017.

Authors

Milos S Simic¹, Andrew Dillin²

Affiliations

¹ Glenn Center for Research on Aging, Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
² Glenn Center for Research on Aging, Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: dillin@berkeley.edu.

PMID: 29727677
DOI: 10.1016/j.stem.2018.04.017

Abstract

Recently in Science, Leeman et al. find that perturbing lysosomal activity of quiescent NSCs directly impedes their ability to become activated, similar to what happens during aging. Excitingly, they could rejuvenate old quiescent NSCs by enhancing the lysosome pathway, ameliorating their ability to clear protein aggregates and become activated.

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MeSH terms

Cell Division
Lysosomes
Neural Stem Cells*