When the Gut Gets Tough, the Enterocytes Get Going

Grischa Y Chen; Janelle S Ayres

doi:10.1016/j.immuni.2018.04.036

When the Gut Gets Tough, the Enterocytes Get Going

Immunity. 2018 May 15;48(5):837-839. doi: 10.1016/j.immuni.2018.04.036.

Authors

Grischa Y Chen¹, Janelle S Ayres²

Affiliations

¹ The Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92103, USA.
² The Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92103, USA. Electronic address: jayres@salk.edu.

PMID: 29768167
DOI: 10.1016/j.immuni.2018.04.036

Abstract

It is assumed that collateral damage from the immune system drives intestinal epithelial cell (IEC) expulsion during enteric infections. In this issue of Immunity, Zhai et al. (2018) describe how Drosophila's canonical immune deficiency (Imd) pathway programs IEC delamination in the gut.

Publication types

Comment

MeSH terms

Animals
Anti-Bacterial Agents
Bacterial Infections
Enterocytes*
Epithelial Cells
NF-kappa B*

Substances

Anti-Bacterial Agents
NF-kappa B

Grants and funding

R01 AI114929/AI/NIAID NIH HHS/United States