Bioorthogonal chemistry in bioluminescence imaging

Aurélien Godinat; Arkadiy A Bazhin; Elena A Goun

doi:10.1016/j.drudis.2018.05.022

Bioorthogonal chemistry in bioluminescence imaging

Drug Discov Today. 2018 Sep;23(9):1584-1590. doi: 10.1016/j.drudis.2018.05.022. Epub 2018 May 18.

Authors

Aurélien Godinat¹, Arkadiy A Bazhin², Elena A Goun³

Affiliations

¹ Institute of Chemical Biology, Department of Chemistry, Imperial College London, London SW7 2AZ, UK.
² Laboratory of Bioorganic Chemistry and Molecular Imaging, Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.
³ Laboratory of Bioorganic Chemistry and Molecular Imaging, Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address: elena.goun@epfl.ch.

PMID: 29778694
DOI: 10.1016/j.drudis.2018.05.022

Abstract

Bioorthogonal chemistry has developed significant over the past few decades, to the particular benefit of molecular imaging. Bioluminescence imaging (BLI) along with other imaging modalities have significantly benefitted from this chemistry. Here, we review bioorthogonal reactions that have been used to signific antly broaden the application range of BLI.

Publication types

Review

MeSH terms

Animals
Chemistry Techniques, Synthetic*
Firefly Luciferin / analogs & derivatives
Firefly Luciferin / chemical synthesis*
Firefly Luciferin / metabolism*
Fluorescent Dyes / chemical synthesis*
Fluorescent Dyes / metabolism*
Genes, Reporter
Humans
Luciferases / genetics
Luciferases / metabolism*
Luminescent Measurements
Molecular Imaging / methods*
Oxidation-Reduction

Substances

Fluorescent Dyes
Firefly Luciferin
Luciferases