Control-oriented physiological modeling of hemodynamic responses to blood volume perturbation

Ramin Bighamian; Bahram Parvinian; Christopher G Scully; George Kramer; Jin-Oh Hahn

doi:10.1016/j.conengprac.2018.01.008

Control-oriented physiological modeling of hemodynamic responses to blood volume perturbation

Control Eng Pract. 2018 Apr;73(April 2018):149-160. doi: 10.1016/j.conengprac.2018.01.008. Epub 2018 Mar 14.

Authors

Ramin Bighamian¹, Bahram Parvinian², Christopher G Scully², George Kramer³, Jin-Oh Hahn⁴

Affiliations

¹ Department of Electrical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
² Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, USA.
³ Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA.
⁴ Department of Mechanical Engineering, University of Maryland, College Park, MD 20742, USA.

Abstract

This paper presents a physiological model to reproduce hemodynamic responses to blood volume perturbation. The model consists of three sub-models: a control-theoretic model relating blood volume response to blood volume perturbation; a simple physics-based model relating blood volume to stroke volume and cardiac output; and a phenomenological model relating cardiac output to blood pressure. A unique characteristic of this model is its balance for simplicity and physiological transparency. Initial validity of the model was examined using experimental data collected from 11 animals. The model may serve as a viable basis for the design and evaluation of closed-loop fluid resuscitation controllers.

Keywords: Blood volume; Fluid infusion; Fluid resuscitation; Hemodynamic response; Hemorrhage; Mathematical model; Physiological closed-loop control.

Grants and funding

FD999999/Intramural FDA HHS/United States