Fecal Calprotectin to Detect Inflammatory Bowel Disease in Juvenile Idiopathic Arthritis

Giovanna Ferrara; Serena Pastore; Lara Sancin; Lucio Torelli; Oriano Radillo; Matteo Bramuzzo; Chiara Bibalo; Alberto Tommasini; Alessandro Ventura; Andrea Taddio

doi:10.3899/jrheum.171200

Fecal Calprotectin to Detect Inflammatory Bowel Disease in Juvenile Idiopathic Arthritis

J Rheumatol. 2018 Oct;45(10):1418-1421. doi: 10.3899/jrheum.171200. Epub 2018 Jun 15.

Authors

Giovanna Ferrara^{1

2}, Serena Pastore^{1

2}, Lara Sancin^{1

2}, Lucio Torelli^{1

2}, Oriano Radillo^{1

2}, Matteo Bramuzzo^{1

2}, Chiara Bibalo^{1

2}, Alberto Tommasini^{1

2}, Alessandro Ventura^{1

2}, Andrea Taddio^{3

4}

Affiliations

¹ From the University of Trieste; Institute for Maternal and Child Health - Institute for Research and Health Care (IRCCS) Burlo Garofolo, Trieste, Italy.
² G. Ferrara, MD, University of Trieste; S. Pastore, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; L. Sancin, MD, University of Trieste; L. Torelli, MSs, University of Trieste; O. Radillo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; M. Bramuzzo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; C. Bibalo, MD, University of Trieste; A. Tommasini, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Ventura, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Taddio, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo.
³ From the University of Trieste; Institute for Maternal and Child Health - Institute for Research and Health Care (IRCCS) Burlo Garofolo, Trieste, Italy. andrea.taddio@burlo.trieste.it.
⁴ G. Ferrara, MD, University of Trieste; S. Pastore, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; L. Sancin, MD, University of Trieste; L. Torelli, MSs, University of Trieste; O. Radillo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; M. Bramuzzo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; C. Bibalo, MD, University of Trieste; A. Tommasini, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Ventura, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Taddio, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo. andrea.taddio@burlo.trieste.it.

PMID: 29907671
DOI: 10.3899/jrheum.171200

Abstract

Objective: This study aimed to test fecal calprotectin (FC) as a screening tool to identify inflammatory bowel disease (IBD) among patients with juvenile idiopathic arthritis (JIA).

Methods: FC level < 100 g/kg was considered normal. Patients with 2 consecutive FC dosage ≥ 100 g/kg underwent endoscopic evaluation.

Results: There were 113 patients with JIA enrolled. FC was raised in 7 patients out of 113. All patients had IBD. In 3/7 patients, high FC levels were the only sign consistent with IBD.

Conclusion: FC is a useful, economical, and noninvasive diagnostic tool to identify JIA patients with underlying IBD.

Keywords: CHRONIC ARTHRITIS; CROHN DISEASE; FECAL CALPROTECTIN; INFLAMMATORY BOWEL DISEASE; JUVENILE IDIOPATHIC ARTHRITIS.

MeSH terms

Adolescent
Arthritis, Juvenile / complications*
Biomarkers / analysis
Child
Child, Preschool
Feces / chemistry*
Female
Humans
Infant
Inflammatory Bowel Diseases / complications*
Inflammatory Bowel Diseases / diagnosis*
Leukocyte L1 Antigen Complex / analysis*
Male
Mass Screening
Retrospective Studies
Young Adult

Substances

Biomarkers
Leukocyte L1 Antigen Complex