IgA nephropathy: new insights into the role of complement

Jürgen Floege; Mohamed R Daha

doi:10.1016/j.kint.2018.03.009

IgA nephropathy: new insights into the role of complement

Kidney Int. 2018 Jul;94(1):16-18. doi: 10.1016/j.kint.2018.03.009.

Authors

Jürgen Floege¹, Mohamed R Daha²

Affiliations

¹ Division of Nephrology and Immunology, RWTH University of Aachen, Aachen, Germany. Electronic address: Juergen.floege@rwth-aachen.de.
² Department of Nephrology, University Medical Center Leiden and University Medical Center Groningen, Groningen, The Netherlands.

PMID: 29933843
DOI: 10.1016/j.kint.2018.03.009

Abstract

Glomerular complement deposition is common in IgA nephropathy, and recent genome-wide association studies point to a role of complement factor H and complement factor H-related proteins in disease susceptibility. A number of recent studies have now documented elevated levels of some factor H-related proteins in IgA nephropathy, which might contribute to enhanced complement activation.

Publication types

Comment

MeSH terms

Complement Activation
Complement Factor H / genetics
Complement System Proteins / genetics
Genome-Wide Association Study
Glomerulonephritis, IGA*
Humans

Substances

Complement Factor H
Complement System Proteins