"Rho"ing a Cellular Boat with Rearward Membrane Flow

George R R Bell; Sean R Collins

doi:10.1016/j.devcel.2018.06.008

"Rho"ing a Cellular Boat with Rearward Membrane Flow

Dev Cell. 2018 Jul 2;46(1):1-3. doi: 10.1016/j.devcel.2018.06.008.

Authors

George R R Bell¹, Sean R Collins²

Affiliations

¹ Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA 95616, USA.
² Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA 95616, USA. Electronic address: srcollins@ucdavis.edu.

PMID: 29974859
DOI: 10.1016/j.devcel.2018.06.008

Abstract

The physicist Edward Purcell wrote in 1977 about mechanisms that cells could use to propel themselves in a low Reynolds number environment. Reporting in Developmental Cell, O'Neill et al. (2018) provide direct evidence for one of these mechanisms by optogenetically driving the migration of cells suspended in liquid through RhoA activation.

Publication types

Comment

MeSH terms

Cell Movement
rho-Associated Kinases
rhoA GTP-Binding Protein*

Substances

rho-Associated Kinases
rhoA GTP-Binding Protein

Grants and funding

DP2 HD094656/HD/NICHD NIH HHS/United States