An Enhancer-Derived RNA Muscles In to Regulate Myogenin In trans

Myles G Garstang; Madapura M M Pradeepa

doi:10.1016/j.molcel.2018.06.024

An Enhancer-Derived RNA Muscles In to Regulate Myogenin In trans

Mol Cell. 2018 Jul 5;71(1):3-5. doi: 10.1016/j.molcel.2018.06.024.

Authors

Myles G Garstang¹, Madapura M M Pradeepa²

Affiliations

¹ Blizard Institute, Barts and The London School of Medicine and Dentistry, QMUL, London E1 2AT, UK; School of Biological Sciences, University of Essex, Colchester CO4 3SQ, UK.
² Blizard Institute, Barts and The London School of Medicine and Dentistry, QMUL, London E1 2AT, UK; School of Biological Sciences, University of Essex, Colchester CO4 3SQ, UK. Electronic address: pradeepa.madapura@gmail.com.

PMID: 29979967
DOI: 10.1016/j.molcel.2018.06.024

Abstract

Noncoding RNAs (ncRNAs) transcribed from active enhancers are known as enhancer RNAs (eRNAs). eRNAs have generally been shown to contribute to transcriptional activation of target genes in cis. In this issue, Tsai et al. (2018) demonstrate that an eRNA expressed from a distal enhancer of Myogenic differentiation1 (MyoD) (^DRReRNA) does not regulate its neighboring MyoD; instead, it promotes myogenic differentiation by activating Myogenin, which is located on a different chromosome.

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MeSH terms

Cell Cycle Proteins
Chromosomal Proteins, Non-Histone
Cohesins
Enhancer Elements, Genetic
Myogenin*
RNA*

Substances

Cell Cycle Proteins
Chromosomal Proteins, Non-Histone
Myogenin
RNA