A safety scoring system finds alprazolam possible to use during breastfeeding.[1] Because of reports of effects in infants, including sedation, alprazolam is probably not the best benzodiazepine for repeated use during nursing, especially with a neonate or premature infant. A shorter-acting benzodiazepine without active metabolites is preferred. If alprazolam is used long term, monitor the infant for sedation, poor feeding and poor weight gain. After a single dose of alprazolam, there is usually no need to wait to resume breastfeeding.