Modeling three-dimensional genomic organization in evolution and pathogenesis

Alon Diament; Tamir Tuller

doi:10.1016/j.semcdb.2018.07.008

Modeling three-dimensional genomic organization in evolution and pathogenesis

Semin Cell Dev Biol. 2019 Jun:90:78-93. doi: 10.1016/j.semcdb.2018.07.008. Epub 2018 Jul 27.

Authors

Alon Diament¹, Tamir Tuller²

Affiliations

¹ Dept. of Biomedical Engineering, Tel Aviv University, Tel Aviv 6997801, Israel.
² Dept. of Biomedical Engineering, Tel Aviv University, Tel Aviv 6997801, Israel; The Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv 6997801, Israel. Electronic address: tamirtul@post.tau.ac.il.

PMID: 30030143
DOI: 10.1016/j.semcdb.2018.07.008

Abstract

The regulation of gene expression is mediated via the complex three-dimensional (3D) conformation of the genetic material and its interactions with various intracellular factors. Various experimental and computational approaches have been developed in recent years for understating the relation between the 3D conformation of the genome and the phenotypes of cells in normal condition and diseases. In this review, we will discuss novel approaches for analyzing and modeling the 3D genomic conformation, focusing on deciphering disease-causing mutations that affect gene expression. We conclude that as this is a very challenging mission, an important direction should involve the comparative analysis of various 3D models from various organisms or cells.

Keywords: Comparative genomics; Computational models; Disease-causing mutations; Gene expression; Three-dimensional genomic organization.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Algorithms
Computational Biology*
Gene Expression
Humans
Models, Genetic*
Phenotype