Background: A ketogenic diet (KD) may have a role in treating patients in super-refractory status epilepticus (SRSE). Sodium-glucose cotransporter 2 (SGLT2) inhibitors have a risk of ketoacidosis that could facilitate induction of KD.
Case summary: A 42-year-old with a history of drug resistant epilepsy developed SRSE requiring several pharmacological interventions during her hospital course including the initiation of KD that failed. SGLT2 inhibitor therapy was initiated in a successful attempt to augment ketone production.
Conclusion: SGLT2 inhibitors may have a therapeutic value in SRSE patients who cannot achieve ketosis with KD alone.
Keywords: Epilepsy; Ketoacidosis; Ketogenic diet; Ketosis; Pentobarbital; Refractory status epilepticus; Seizure; Sodium-glucose cotransporter 2 inhibitor; Status epilepticus; Super-refractory status epilepticus.