Abstract
A BamHI polymorphism has been identified in the human factor IX gene. This polymorphism, which occurs in approximately 6% of X chromosomes, has been used to determine the carrier status of a female in a family with a history of hemophilia B. This family was uninformative for the previously reported TaqI and Xmnl polymorphisms in the factor IX gene.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bacterial Proteins*
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DNA / analysis
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DNA Restriction Enzymes / metabolism*
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Deoxyribonuclease BamHI
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Deoxyribonucleases, Type II Site-Specific*
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Factor IX / genetics*
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Female
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Genetic Carrier Screening*
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Hemophilia B / genetics*
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Humans
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Male
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Pedigree
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Polymorphism, Genetic*
Substances
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Bacterial Proteins
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Factor IX
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DNA
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DNA Restriction Enzymes
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Deoxyribonuclease BamHI
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endodeoxyribonuclease PaeI
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BglII endonuclease
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Deoxyribonucleases, Type II Site-Specific