Intraoperative fluorescence imaging in thoracic surgery

J Surg Oncol. 2018 Aug;118(2):344-355. doi: 10.1002/jso.25149. Epub 2018 Aug 11.

Abstract

Intraoperative fluorescence imaging (IFI) can improve real-time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery have demonstrated that IFI with second window indocyanine green (TumorGlow® ) can identify subcentimeter pulmonary nodules, anterior mediastinal masses, and mesothelioma, while the use of a folate receptor-targeted near-infrared agent, OTL38, can improve the specificity for diagnosing tumors with folate receptor expression. Here, we review the existing preclinical and clinical data on IFI in thoracic surgery.

Keywords: OTL38; indocyanine green (ICG); intraoperative fluorescence imaging (IFI); near-infrared (NIR) fluorescence imaging; thoracic surgery.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma / diagnostic imaging
  • Adenocarcinoma / surgery
  • Adenocarcinoma of Lung
  • Clinical Trials as Topic
  • Fluorescent Dyes
  • Humans
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / surgery
  • Mediastinal Neoplasms / diagnostic imaging
  • Mediastinal Neoplasms / surgery
  • Mesothelioma / diagnostic imaging
  • Mesothelioma / surgery
  • Monitoring, Intraoperative / methods
  • Optical Imaging / methods*
  • Solitary Pulmonary Nodule / diagnostic imaging
  • Solitary Pulmonary Nodule / surgery
  • Surgery, Computer-Assisted / methods*
  • Thoracic Neoplasms / diagnostic imaging*
  • Thoracic Neoplasms / surgery*
  • Thoracic Surgical Procedures / methods*

Substances

  • Fluorescent Dyes