Colon cancer is a heterogeneous tumor driven by subpopulations of cancer stem cells (CSCs). We recently used patient-derived organoids (PDOs) to demonstrate that CSC survival is regulated by autocrine non-canonical Hedgehog signaling, which acts as a positive regulator of Wnt signaling to block CSC differentiation.
Keywords: Cancer Organoid; Cancer Stem Cell; Colon Cancer; Non-canonical Hedgehog signaling; WNT pathway.