Rapping about Mechanotransduction

Consuelo Ibar; Kenneth D Irvine

doi:10.1016/j.devcel.2018.09.007

Rapping about Mechanotransduction

Dev Cell. 2018 Sep 24;46(6):678-679. doi: 10.1016/j.devcel.2018.09.007.

Authors

Consuelo Ibar¹, Kenneth D Irvine²

Affiliations

¹ Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.
² Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: irvine@waksman.rutgers.edu.

PMID: 30253168
DOI: 10.1016/j.devcel.2018.09.007

Abstract

Mechanical cues can regulate cell proliferation and differentiation through the Hippo-YAP signaling network. Reporting in Nature, Meng et al. (2018) show that the Ras-related GTPase RAP2 connects extracellular matrix stiffness to Hippo pathway regulation, adding to our understanding of how mechanical cues are converted into changes in YAP activity.

Publication types

Comment

MeSH terms

Adaptor Proteins, Signal Transducing*
Cell Proliferation
Extracellular Matrix
Mechanotransduction, Cellular*
Phosphoproteins
Signal Transduction

Substances

Adaptor Proteins, Signal Transducing
Phosphoproteins