Interferon regulatory factors: Where to stand in transplantation

Transpl Immunol. 2018 Dec:51:76-80. doi: 10.1016/j.trim.2018.10.001. Epub 2018 Oct 16.

Abstract

Interferon regulatory factors (IRFs) are implicated in regulating inflammatory responses to pathogens and alloantigens. Since transplantation is usually accompanied by ischemia reperfusion injury (IRI), acute and chronic rejections, as well as immunodeficiency due to immunosuppressive drugs, IRFs seem to play a considerable role in allograft outcome. For instance, IRF-1 has been shown to be involved in pathogenesis of IRI; however, IRF-2 exhibits an opposite function. Some IRF-3 and 5 SNPs are associated with better or worse graft survival rates. Of note, IRF-4 inhibition has resulted in improved transplant outcomes. Herein we review available studies about IRFs influence on various stages of transplantation.

Keywords: Interferon regulatory factor; Ischemia reperfusion injury; Rejection; Transplantation.

Publication types

  • Review

MeSH terms

  • Animals
  • Genetic Predisposition to Disease
  • Graft Rejection / immunology*
  • Graft Survival
  • Humans
  • Immunosuppression Therapy
  • Interferon Regulatory Factors / genetics
  • Interferon Regulatory Factors / metabolism*
  • Interferons / metabolism*
  • Organ Transplantation*
  • Polymorphism, Single Nucleotide
  • Reperfusion Injury / immunology*

Substances

  • Interferon Regulatory Factors
  • Interferons