The occurrence of bisphenol plasticizers in paired dust and urine samples and its association with oxidative stress

Min Liu; Shenglan Jia; Ting Dong; Yuan Han; Jingchuan Xue; Elvy Riani Wanjaya; Mingliang Fang

doi:10.1016/j.chemosphere.2018.10.090

The occurrence of bisphenol plasticizers in paired dust and urine samples and its association with oxidative stress

Chemosphere. 2019 Feb:216:472-478. doi: 10.1016/j.chemosphere.2018.10.090. Epub 2018 Oct 16.

Authors

Min Liu¹, Shenglan Jia², Ting Dong³, Yuan Han⁴, Jingchuan Xue⁵, Elvy Riani Wanjaya⁴, Mingliang Fang⁶

Affiliations

¹ Residues and Resource Reclamation Centre (R3C), Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 CleanTech Loop, CleanTech One, 637141, Singapore; School of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.
² Residues and Resource Reclamation Centre (R3C), Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 CleanTech Loop, CleanTech One, 637141, Singapore.
³ School of Environment and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, 511443, China.
⁴ Analytics Cluster, Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 CleanTech Loop, CleanTech One, 637141, Singapore.
⁵ Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27519, USA.
⁶ Residues and Resource Reclamation Centre (R3C), Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 CleanTech Loop, CleanTech One, 637141, Singapore; School of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore; Analytics Cluster, Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 CleanTech Loop, CleanTech One, 637141, Singapore. Electronic address: mlfang@ntu.edu.sg.

PMID: 30388685
DOI: 10.1016/j.chemosphere.2018.10.090

Abstract

Bisphenol A diglycidy ether (BADGE) and its derivatives are epoxy resins and widely used as emerging plasticizers in food packages and material coating. Though known as endocrine disruptors, little information is available on their occurrence, exposure routes and toxicity. Besides, the analysis of BADGE and its derivatives has always been a challenge due to their reactive chemical properties and the background contamination. Therefore, we firstly developed a novel water-free method to analyze BADGE and its derivatives in dust samples together with other two typical plasticizers bisphenol A (BPA) and bisphenol S (BPS). In order to investigate the levels in paired dust and urine samples, 33 paired samples were collected from Singapore. In both dust and urine samples, the predominant compounds were BPA, BADGE-2H₂O and BPS. A significantly positive correlation of BPA levels in paired dust and urine samples was observed in this small-scale study. To tentatively explore the human health effect from exposure to these bisphenol plasticizers, we assessed the correlation between the urinary concentrations of these compounds and oxo-2'-deoxyguanosine (8-OHdG), an oxidative stress biomarker. The result showed that 8-OHdG levels in urine samples was positively correlated with urinary BPA level and body mass index (BMI), suggesting that elevated oxidative stress might be associated with BPA exposure and obesity. In the future, a larger scale study is warranted due to the limited sample size in this study.

Keywords: Bisphenol A diglycidyl ether; Bisphenol plasticizers; Dust; Urine; and oxidative stress.

MeSH terms

Benzhydryl Compounds / chemistry*
Benzhydryl Compounds / urine
Biomarkers
Dust / analysis*
Humans
Oxidative Stress / physiology*
Phenols / chemistry*
Phenols / urine
Plasticizers / chemistry*

Substances

Benzhydryl Compounds
Biomarkers
Dust
Phenols
Plasticizers
bisphenol A