Immunoglobulin E blockade during food allergen ingestion enhances the induction of inhibitory immunoglobulin G antibodies

Amanda J Stranks; Samantha C Minnicozzi; Samuel J Miller; Oliver T Burton; Stephanie L Logsdon; Jonathan M Spergel; Kari C Nadeau; Jacqueline A Pongracic; Dale T Umetsu; Rima Rachid; Andrew J MacGinnitie; Lynda C Schneider; Hans C Oettgen

doi:10.1016/j.anai.2018.10.024

Immunoglobulin E blockade during food allergen ingestion enhances the induction of inhibitory immunoglobulin G antibodies

Ann Allergy Asthma Immunol. 2019 Feb;122(2):213-215. doi: 10.1016/j.anai.2018.10.024. Epub 2018 Nov 4.

Affiliations

¹ Division of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Currently: University of Cambridge, Cambridge, United Kingdom.
² Division of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
³ Division of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.
⁴ Division of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Currently: Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, Ohio.
⁵ Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
⁶ Department of Medicine, Stanford University, Palo Alto, California.
⁷ Department of Allergy and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
⁸ Genentech, South San Francisco, California.
⁹ Division of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts. Electronic address: Hans.Oettgen@childrens.harvard.edu.

No abstract available

Publication types

Letter
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Anti-Idiotypic / therapeutic use*
Desensitization, Immunologic*
Humans
Immunoglobulin G / biosynthesis*
Omalizumab / therapeutic use*
Peanut Hypersensitivity / immunology
Peanut Hypersensitivity / therapy*

Substances

Antibodies, Anti-Idiotypic
Immunoglobulin G
anti-IgE antibodies
Omalizumab

Immunoglobulin E blockade during food allergen ingestion enhances the induction of inhibitory immunoglobulin G antibodies

Authors

Affiliations

Publication types

MeSH terms

Substances

Grants and funding