The Inner Nuclear Membrane Takes On Lipid Metabolism

Holly Merta; Shirin Bahmanyar

doi:10.1016/j.devcel.2018.11.005

The Inner Nuclear Membrane Takes On Lipid Metabolism

Dev Cell. 2018 Nov 19;47(4):397-399. doi: 10.1016/j.devcel.2018.11.005.

Authors

Holly Merta¹, Shirin Bahmanyar²

Affiliations

¹ Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.
² Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA. Electronic address: shirin.bahmanyar@yale.edu.

PMID: 30458132
DOI: 10.1016/j.devcel.2018.11.005

Abstract

Challenging the idea of the inner nuclear membrane (INM) being an inert compartment, recent work in S. cerevisiae shows that the INM can metabolize lipids and that local lipid metabolism can regulate transcription in response to lipid availability, suggesting a functional role for the INM in cellular lipid homeostasis.

Publication types

Comment

MeSH terms

Lipid Droplets
Lipid Metabolism
Lipids
Membrane Proteins
Nuclear Envelope*
Saccharomyces cerevisiae*

Substances

Lipids
Membrane Proteins

Grants and funding

R01 GM131004/GM/NIGMS NIH HHS/United States