Gene-gene and gene-environment interaction data for platinum-based chemotherapy in non-small cell lung cancer

Lei-Yun Wang; Jia-Jia Cui; Jun-Yan Liu; Ao-Xiang Guo; Zhen-Yu Zhao; Ying-Zi Liu; Ji-Chu Wu; Min Li; Cheng-Ping Hu; Yang Gao; Hong-Hao Zhou; Ji-Ye Yin

doi:10.1038/sdata.2018.284

Gene-gene and gene-environment interaction data for platinum-based chemotherapy in non-small cell lung cancer

Sci Data. 2018 Dec 11:5:180284. doi: 10.1038/sdata.2018.284.

Authors

Lei-Yun Wang^{1

2}, Jia-Jia Cui^{1

2}, Jun-Yan Liu³, Ao-Xiang Guo^{1

2}, Zhen-Yu Zhao^{1

2}, Ying-Zi Liu^{1

2}, Ji-Chu Wu⁴, Min Li⁵, Cheng-Ping Hu⁵, Yang Gao⁶, Hong-Hao Zhou^{1

2}, Ji-Ye Yin^{1

2

7}

Affiliations

¹ Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.
² Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China.
³ Department of orthopaedics, The First Affiliated Hospital of the University of South China, Hengyang 421001, P. R. China.
⁴ Department of Cardiovascular, Central Hospital of Shaoyang, Shaoyang 422000, P. R. China.
⁵ Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.
⁶ Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha 410008, Changsha, P.R. China.
⁷ Hunan Provincial Gynecological Cancer Diagnosis and Treatment Engineering Research Center, Changsha 410078, P. R. China.

Abstract

Gene-gene (GXG) and gene-environment (GXE) interactions play important roles in pharmacogenetics study. Simultaneously incorporating multiple single nucleotide polymorphisms (SNPs) and clinical factors is needed to explore the association of their interactions with drug response and toxicity phenotypes. We genotyped 504 SNPs in a total of 490 Chinese non-small cell lung cancer (NSCLC) patients, and the correlation of GXG and GXE interactions with platinum-based chemotherapeutic efficacy and safety were analyzed. In this data descriptor, we shared our data set which could help others to reuse them. All kinds of file types needed for GXG and GXE analysis were supplied. The process of genotyping and data analysis was also introduced step by step.

Publication types

Dataset
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / therapeutic use
Asian People
Carcinoma, Non-Small-Cell Lung / drug therapy
Carcinoma, Non-Small-Cell Lung / genetics*
Epistasis, Genetic*
Gene-Environment Interaction*
Humans
Lung Neoplasms / drug therapy
Lung Neoplasms / genetics*
Platinum Compounds / therapeutic use
Polymorphism, Single Nucleotide

Substances

Antineoplastic Agents
Platinum Compounds

Associated data

figshare/10.6084/m9.figshare.c.4135967