Cell metabolism as a potentially targetable pathway in RA

Nat Rev Rheumatol. 2019 Feb;15(2):70-72. doi: 10.1038/s41584-018-0148-8.

Authors

Trudy McGarry^{1

2}, Ursula Fearon³

Affiliations

¹ Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
² Centre for Arthritis and Rheumatic Diseases, St Vincent's University Hospital, University College Dublin, Dublin, Ireland.
³ Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. fearonu@tcd.ie.

PMID: 30560909
DOI: 10.1038/s41584-018-0148-8

No abstract available

Publication types

Review

MeSH terms

Animals
Arthritis, Rheumatoid / drug therapy*
Endothelial Cells / metabolism
Glycogen Synthase Kinase 3 beta / metabolism
Glycolysis / drug effects
Hexokinase / antagonists & inhibitors
Humans
Macrophages / metabolism
Molecular Targeted Therapy*
Receptors, G-Protein-Coupled / metabolism
Synoviocytes / enzymology

Substances

Receptors, G-Protein-Coupled
SUCNR1 protein, human
HK2 protein, human
Hexokinase
Glycogen Synthase Kinase 3 beta