Abstract
Embryonic ventral forebrain grafts containing developing cholinergic cells were transplanted to the neocortex of rats with bilateral quisqualic acid lesions of the nucleus basalis magnocellularis. A lesion-induced deficit on performance of a spatial alternation test of memory was reduced by such transplants. When the same animals were treated with the acetylcholinesterase inhibitor physostigmine (0.05 mg/kg), however, performance on the behavioral task was not further promoted, and therefore, under these conditions, the cholinergic cortical transplants appear not to be subject to modulation by anticholinesterase drugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / metabolism
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Animals
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Basal Ganglia / drug effects
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Basal Ganglia / physiology*
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Cerebral Cortex / physiology*
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Cholinergic Fibers / drug effects
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Cholinergic Fibers / physiology
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Cholinergic Fibers / transplantation*
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Frontal Lobe / cytology
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Frontal Lobe / embryology
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Frontal Lobe / transplantation*
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Male
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Memory Disorders / physiopathology*
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Oxadiazoles
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Physostigmine / pharmacology
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Quisqualic Acid
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Rats
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Rats, Inbred Strains
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Spatial Behavior / drug effects
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Spatial Behavior / physiology*
Substances
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Oxadiazoles
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Quisqualic Acid
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Physostigmine
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Acetylcholinesterase