Concise synthesis of (±)-litseaones A and B

Hideaki Kageji; Naoki Mori; Hirosato Takikawa; Hidenori Watanabe

doi:10.1080/09168451.2018.1562881

Concise synthesis of (±)-litseaones A and B

Biosci Biotechnol Biochem. 2019 May;83(5):810-812. doi: 10.1080/09168451.2018.1562881. Epub 2018 Dec 30.

Authors

Hideaki Kageji¹, Naoki Mori¹, Hirosato Takikawa¹, Hidenori Watanabe¹

Affiliation

¹ a Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences , The University of Tokyo , Tokyo , Japan.

PMID: 30596347
DOI: 10.1080/09168451.2018.1562881

Abstract

A concise synthesis of litseaones A and B, which were isolated from the stem barks of Litsea rubescens and L. pedunculata, is described in this study. Litseaone A was synthesized in just three steps from a known phloroglucinol derivative. The direct conversion of litseaone A into litseaone B was also achieved.

Keywords: Synthesis; cytotoxic; litseaones A and B; protecting-group-free.

MeSH terms

Flavonoids / chemical synthesis*
Flavonoids / chemistry
Litsea / chemistry*
Molecular Structure
Phloroglucinol / chemistry
Plant Bark / chemistry
Plant Stems / chemistry
Proton Magnetic Resonance Spectroscopy
Spectroscopy, Fourier Transform Infrared
Stereoisomerism

Substances

Flavonoids
litseaone A
litseaone B
Phloroglucinol