HBV Genotype-Specific Levels of Hepatitis B Surface Antigen Improve HBV Phenotype Definition

Clin Gastroenterol Hepatol. 2020 Jan;18(1):259-261. doi: 10.1016/j.cgh.2018.12.039. Epub 2019 Jan 7.

Abstract

Controversies exist regarding the classification of the different clinical phases of chronic hepatitis B (CHB) because hepatitis B virus (HBV) DNA and alanine aminotransferase levels fluctuate over time.1,2 To improve the distinction of clinical phases and the associated spectrum of clinical outcome,3,4 hepatitis B surface antigen (HBsAg) levels may be of help.5-7 We hypothesize that HBV genotype specific HBsAg levels are needed for the identification of different clinical HBV disease phases.7.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Canada
  • Cross-Sectional Studies
  • DNA, Viral / analysis
  • Genotype
  • Hepatitis B Surface Antigens / genetics*
  • Hepatitis B virus / genetics*
  • Hepatitis B, Chronic / classification
  • Hepatitis B, Chronic / diagnosis
  • Hepatitis B, Chronic / genetics*
  • Hepatitis B, Chronic / virology*
  • Humans
  • Phenotype
  • United States

Substances

  • DNA, Viral
  • Hepatitis B Surface Antigens