Associations between neuroanatomical abnormality and motor symptoms in paroxysmal kinesigenic dyskinesia

Parkinsonism Relat Disord. 2019 May:62:134-140. doi: 10.1016/j.parkreldis.2018.12.029. Epub 2019 Jan 2.

Abstract

Introduction: The pathophysiologic mechanism of paroxysmal kinesigenic dyskinesia (PKD) is largely unclear. Basal ganglia-thalamo-cortical circuit involvement is thought to underlie PKD pathophysiology. However, microstructural alternations in the motor circuit of PKD require further elucidation.

Methods: Diffusion tensor imaging and high-resolution T1-weighted imaging were performed on 30 PKD patients (15 PRRT2 carriers, 15 PRRT2 non-carriers) and 15 matched healthy controls. Tract-based spatial statistics were conducted on diffusion indices to examine microstructural integrity of white matter. Voxel-based morphometry analysis was used to examine volumetric changes of gray matter. Multiple regression was employed to test the contribution of demography, disease duration, and PRRT2 status to pathological changes in brain structure.

Results: Six (including two novel) PRRT2 mutations were identified in PKD patients who exhibited significantly reduced mean diffusivity mainly along the left corticospinal tract, and reduced gray matter volume in pre-supplementary motor area (preSMA) and right opercular part of inferior frontal gyrus (IFGoperc), compared to healthy controls. Both gray matter volume reductions in preSMA and diffusion indices of abnormal white matter negatively correlated with disease duration. Genotype-phenotype analysis revealed that PRRT2 mutation carriers had earlier onset age, longer attacks, and a larger proportion of bilateral symptoms than non-carriers.

Conclusions: We observed that PRRT2 mutations were associated with disease severity, while neuroanatomical abnormality was associated with disease duration in patients with PKD. Aberrant microstructural changes in preSMA and IFG areas, independent of mutation status, point to dysregulated motor inhibition in patients and provide new insights into neurobiological mechanisms underlying motor symptoms of PKD.

Keywords: Corticospinal tract; Gray matter volume; Motor symptoms; PRRT2 mutations; Paroxysmal kinesigenic dyskinesia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Brain / anatomy & histology
  • Brain / diagnostic imaging*
  • Cohort Studies
  • Dystonia / diagnostic imaging*
  • Dystonia / genetics*
  • Female
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Motor Disorders / diagnostic imaging*
  • Motor Disorders / genetics*
  • Mutation / genetics
  • Young Adult

Supplementary concepts

  • Familial paroxysmal dystonia