Is Fasting Necessary for Individuals With Nonalcoholic Fatty Liver Disease to Undergo Vibration-Controlled Transient Elastography?

Raj Vuppalanchi; Regina Weber; Sarah Russell; Samer Gawrieh; Niharika Samala; James E Slaven; Lauren Harden; Naga Chalasani

doi:10.14309/ajg.0000000000000116

Is Fasting Necessary for Individuals With Nonalcoholic Fatty Liver Disease to Undergo Vibration-Controlled Transient Elastography?

Am J Gastroenterol. 2019 Jun;114(6):995-997. doi: 10.14309/ajg.0000000000000116.

Authors

Raj Vuppalanchi¹, Regina Weber¹, Sarah Russell¹, Samer Gawrieh¹, Niharika Samala¹, James E Slaven², Lauren Harden¹, Naga Chalasani¹

Affiliations

¹ Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
² Department of Biostatistics, Indiana University-Purdue University, Indianapolis, Indiana, USA.

PMID: 30694869
DOI: 10.14309/ajg.0000000000000116

Abstract

Objectives: To investigate the effect of meal intake on liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) in patients with biopsy-proven nonalcoholic fatty liver disease undergoing vibration-controlled transient elastography.

Methods: LSM and CAP were assessed at baseline and serially for 6 hours after meal intake in 24 patients.

Results: A significant increase in LSM was seen up to the 2-hour time point (26 ± 25%, P = 0.02). The CAP scores changed minimally with a maximal change of 3% (P > 0.1).

Conclusions: Three hours of fasting is necessary before evaluation with vibration-controlled transient elastography.

MeSH terms

Eating
Elasticity Imaging Techniques / methods*
Fasting*
Female
Follow-Up Studies
Humans
Liver / diagnostic imaging*
Male
Middle Aged
Non-alcoholic Fatty Liver Disease / diagnosis
Non-alcoholic Fatty Liver Disease / therapy*
Postprandial Period
Prognosis
ROC Curve
Severity of Illness Index