A single group quasi-experimental study was conducted among 40 women on the flrst day after they underwent mastectomy. Subjects were selected by convenience sampling technique. A single sessionfoot reflexology was administered among post-mastectomy women. Pain was assessed at baseline, post-test I (immediately after foot reflexology) and post-test II (30 minutes after foot reflexology). The findings revealed that there was a statistically significant difference between the pain scores at baseline and both the post-tests (t (39) = 2.9, p <0.05 and t ,(39)= - 4.418, p < 0.05). A statistically significant reduction in physiologic parameters was also observed from the baseline (systolic BP at post-test I (t(39) = 2.470, p < 0.05).