Complement and Transplantation: From New Mechanisms to Potential Biomarkers and Novel Treatment Strategies

Julian K Horwitz; Nicholas H Chun; Peter S Heeger

doi:10.1016/j.cll.2018.10.004

Complement and Transplantation: From New Mechanisms to Potential Biomarkers and Novel Treatment Strategies

Clin Lab Med. 2019 Mar;39(1):31-43. doi: 10.1016/j.cll.2018.10.004. Epub 2018 Dec 20.

Authors

Julian K Horwitz¹, Nicholas H Chun², Peter S Heeger³

Affiliations

¹ Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA; Department of Surgery, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA.
² Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA.
³ Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA; The Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA. Electronic address: peter.heeger@mssm.edu.

Abstract

The complement system, traditionally considered a component of innate immunity, is now recognized as a crucial mediator of the adaptive immune response in solid organ transplantation. Preclinical and early human trials have demonstrated the importance of complement effector mechanisms in driving allograft injury during specific antigraft immune responses, including ischemia-reperfusion injury, T-cell-mediated rejection, and antibody-mediated rejection, as well as a potential role for complement-derived risk stratification biomarkers. These data support the need for further testing of complement inhibitors in solid organ transplant recipients.

Keywords: Antibody-mediated rejection; Complement; Ischemia-reperfusion injury; T cells.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Adaptive Immunity*
Animals
Biomarkers
Complement System Proteins / physiology*
Graft Rejection / immunology*
Humans
Immunity, Innate
Mice
Models, Immunological*
Reperfusion Injury / immunology
T-Lymphocytes

Substances

Biomarkers
Complement System Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding