Genetic polymorphism of 27 X-chromosomal short tandem repeats in an Egyptian population

Mamiko Fukuta; Mohammed Gaballah; Kazushi Takada; Hiroki Miyazaki; Hideaki Kato; Yasuhiro Aoki; Sameera Sh Hamed; Doaa A A ElMorsi; Sahar A ElDakroory

doi:10.1016/j.legalmed.2019.01.009

Genetic polymorphism of 27 X-chromosomal short tandem repeats in an Egyptian population

Leg Med (Tokyo). 2019 Mar:37:64-66. doi: 10.1016/j.legalmed.2019.01.009. Epub 2019 Jan 24.

Authors

Mamiko Fukuta¹, Mohammed Gaballah², Kazushi Takada³, Hiroki Miyazaki³, Hideaki Kato³, Yasuhiro Aoki³, Sameera Sh Hamed⁴, Doaa A A ElMorsi⁴, Sahar A ElDakroory⁴

Affiliations

¹ Department of Forensic Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. Electronic address: m.fukuta@med.nagoya-cu.ac.jp.
² Egyptian Forensic Medicine Authority, Ministry of Justice, Cairo, Egypt.
³ Department of Forensic Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
⁴ Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

PMID: 30711876
DOI: 10.1016/j.legalmed.2019.01.009

Abstract

We presented allele frequencies of 27 X-chromosomal short tandem repeats (DXS6807, DXS9902, DXS6795, DXS6810, DXS10076, DXS10077, DXS10078, DXS10162, DXS10163, DXS10164, DXS7132, DXS981, DXS6800, DXS6803, DXS6809, DXS6789, DXS6799, DXS7424, DXS101, DXS7133, GATA172D05, DXS10103, HPRTB, GATA31E08, DXS8377, DXS10147, and DXS7423) obtained from 352 unrelated individuals in Egypt. No deviation from Hardy-Weinberg equilibrium was detected. Two pairs of adjacent loci showed significant linkage disequilibrium. In the principal component analysis plot, the Egyptian data were located between Europe and sub-Saharan Africa, away from Asia.

Keywords: Egypt; Short tandem repeats (STR); X-chromosome.

MeSH terms

Chromosomes, Human, X / genetics*
Egypt
Female
Gene Frequency / genetics*
Genetic Loci / genetics
Humans
Linkage Disequilibrium / genetics
Male
Microsatellite Repeats / genetics*
Polymorphism, Genetic / genetics*