Gonococcal infection: An unresolved problem

Enferm Infecc Microbiol Clin (Engl Ed). 2019 Aug-Sep;37(7):458-466. doi: 10.1016/j.eimc.2018.12.008. Epub 2019 Feb 4.
[Article in English, Spanish]

Abstract

Gonococcal infection is a current public health problem worldwide, being the second most prevalent bacterial sexually transmitted infection. The etiologic agent is Neisseria gonorrhoeae, a gram-negative diplococcus, and mainly causes urethritis in men. In women up to 50% of infections can be asymptomatic. N. gonorrhoeae has a great ability to develop antibiotic resistance, so the last remaining therapeutic option are extended spectrum cephalosporins. Many guides recommend dual therapy with ceftriaxone and azithromycin, but in recent years the resistance to azithromycin is also increasing, so that dual treatment is being questioned by scientific societies.

Keywords: Diagnosis; Diagnóstico; Gonococcal infection; Infección gonocócica; Tratamiento; Treatment.

Publication types

  • Review

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Child
  • Child Abuse, Sexual
  • Contact Tracing
  • Disease Transmission, Infectious / prevention & control
  • Drug Resistance, Multiple, Bacterial
  • Drug Therapy, Combination
  • Female
  • Global Health
  • Gonorrhea / congenital
  • Gonorrhea / drug therapy*
  • Gonorrhea / epidemiology
  • Gonorrhea / transmission
  • Humans
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical / prevention & control
  • Male
  • Neisseria gonorrhoeae / drug effects*
  • Ophthalmia Neonatorum / drug therapy
  • Ophthalmia Neonatorum / epidemiology
  • Ophthalmia Neonatorum / microbiology
  • Pregnancy
  • Pregnancy Complications, Infectious / microbiology
  • Sexual Behavior
  • Urethritis / drug therapy
  • Urethritis / epidemiology
  • Urethritis / microbiology
  • Uterine Cervicitis / drug therapy
  • Uterine Cervicitis / epidemiology
  • Uterine Cervicitis / microbiology

Substances

  • Anti-Bacterial Agents