Dissecting Cell Lineages: From Microscope to Kaleidoscope

Unmesh Jadhav; Ramesh A Shivdasani

doi:10.1016/j.cell.2019.01.054

Dissecting Cell Lineages: From Microscope to Kaleidoscope

Cell. 2019 Feb 21;176(5):949-951. doi: 10.1016/j.cell.2019.01.054.

Authors

Unmesh Jadhav¹, Ramesh A Shivdasani²

Affiliations

¹ Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.
² Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02215, USA. Electronic address: ramesh_shivdasani@dfci.harvard.edu.

PMID: 30794779
DOI: 10.1016/j.cell.2019.01.054

Abstract

Single-cell transcriptomics coupled with dynamic two-color fluorescence are used by Gehart et al. (2019) to elucidate adult mammalian cell trajectories in real time. The authors' close examination of intestinal enteroendocrine differentiation reveals new lineage features and shifting cell identities, and experiments in organoids uncover specific roles for transcriptional regulators identified by this approach.

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MeSH terms

Animals
Cell Differentiation
Cell Lineage
Intestines
Organoids*
Stem Cells*