PET/Computed Tomography Evaluation of Infection of the Heart

PET Clin. 2019 Apr;14(2):251-269. doi: 10.1016/j.cpet.2018.12.006. Epub 2019 Feb 1.

Abstract

The 2015 European Society of Cardiology guidelines for the management of infective endocarditis included 18F-fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT) in the diagnostic work-up of prosthetic valve endocarditis. This article examines the literature from the last 3 years to highlight the additional role 18F-FDG-PET/CT can contribute to an accurate diagnosis of cardiac infections and associated infectious complications. The challenges and pitfalls associated with 18F-FDG-PET/CT in such clinical settings must be recognized and these are discussed along with the suggested protocols that may be incorporated in an attempt to address these issues.

Keywords: Cardiac device; Endocarditis; Graft infection; Infection; Left ventricular assist device; PET; Pacemaker.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Electrodes, Implanted / adverse effects
  • Endocarditis / diagnostic imaging*
  • Endocarditis / drug therapy
  • False Negative Reactions
  • Fluorodeoxyglucose F18
  • Heart Valve Prosthesis / adverse effects
  • Heart Valve Prosthesis Implantation / adverse effects
  • Heart-Assist Devices / adverse effects
  • Humans
  • Image Interpretation, Computer-Assisted
  • Positron Emission Tomography Computed Tomography / methods*
  • Prosthesis-Related Infections / diagnostic imaging
  • Prosthesis-Related Infections / drug therapy
  • Radiopharmaceuticals

Substances

  • Anti-Bacterial Agents
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18