High yield synthesis of 6-[18F]fluoro-L-dopa

J Nucl Med. 1986 Mar;27(3):417-21.

Abstract

The radiofluorination of L-dopa with [18F]F2 was investigated with the purpose of improving the yield of 6-[18F]fluoro-L-dopa. When boron trifluoride was added to the reaction mixture in hydrogen fluoride (HF), the yield was increased threefold. Nine millicuries of 6-[18F]fluoro-L-dopa were produced from 100 mCi [18F]F2 routinely and reliably after 2 hr of preparation. If acetonitrile or water were substituted for HF, little or no 6-fluoro-L-dopa was made.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arsenic
  • Arsenicals*
  • Boranes
  • Chromatography, High Pressure Liquid / methods
  • Dihydroxyphenylalanine / analogs & derivatives*
  • Dihydroxyphenylalanine / chemical synthesis
  • Fluorides
  • Fluorine*
  • Isomerism
  • Isotope Labeling / methods*
  • Levodopa / analogs & derivatives
  • Radioisotopes*
  • Silanes
  • Silicon Compounds*
  • Solvents

Substances

  • Arsenicals
  • Boranes
  • Radioisotopes
  • Silanes
  • Silicon Compounds
  • Solvents
  • Fluorine
  • fluorodopa F 18
  • Levodopa
  • Dihydroxyphenylalanine
  • silicon tetrafluoride
  • boron trifluoride
  • arsenic pentafluoride
  • levodopa methyl ester
  • Arsenic
  • Fluorides