Abstract
The radiofluorination of L-dopa with [18F]F2 was investigated with the purpose of improving the yield of 6-[18F]fluoro-L-dopa. When boron trifluoride was added to the reaction mixture in hydrogen fluoride (HF), the yield was increased threefold. Nine millicuries of 6-[18F]fluoro-L-dopa were produced from 100 mCi [18F]F2 routinely and reliably after 2 hr of preparation. If acetonitrile or water were substituted for HF, little or no 6-fluoro-L-dopa was made.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Arsenic
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Arsenicals*
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Boranes
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Chromatography, High Pressure Liquid / methods
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Dihydroxyphenylalanine / analogs & derivatives*
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Dihydroxyphenylalanine / chemical synthesis
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Fluorides
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Fluorine*
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Isomerism
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Isotope Labeling / methods*
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Levodopa / analogs & derivatives
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Radioisotopes*
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Silanes
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Silicon Compounds*
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Solvents
Substances
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Arsenicals
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Boranes
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Radioisotopes
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Silanes
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Silicon Compounds
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Solvents
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Fluorine
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fluorodopa F 18
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Levodopa
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Dihydroxyphenylalanine
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silicon tetrafluoride
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boron trifluoride
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arsenic pentafluoride
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levodopa methyl ester
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Arsenic
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Fluorides