Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A

Int J Nanomedicine. 2018 Mar 15;13(T-NANO 2014 Abstracts):19-23. doi: 10.2147/IJN.S125009. eCollection 2018.

Abstract

Methoxyphenyl piperazine is a versatile pharmacophore and has been exploited for targeting 5HT1A receptors. In the present study, silver nanoparticles were conjugated (capped) with methoxyphenyl piperazine-dithiocarbamate for application as targeted optical imaging agent at extremely low detection limits. Our results demonstrate an easy synthesis of the ligand methoxyphenyl piperazine-dithiocarbamate and silver nanoparticles and their conjugation was free from extraneous impurities.

Keywords: optical imaging; receptor imaging; targeted nanoparticles.

MeSH terms

  • Ditiocarb / chemical synthesis*
  • Ditiocarb / chemistry
  • Imaging, Three-Dimensional*
  • Ligands
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / ultrastructure
  • Molecular Docking Simulation*
  • Piperazines / chemical synthesis*
  • Piperazines / chemistry
  • Receptor, Serotonin, 5-HT1A / metabolism*
  • Silver / chemistry*
  • Spectrophotometry, Ultraviolet
  • X-Ray Diffraction

Substances

  • Ligands
  • Piperazines
  • Receptor, Serotonin, 5-HT1A
  • 1-(2-methoxyphenyl)piperazine
  • Silver
  • Ditiocarb