Systemic Notch downregulation promotes KrasG12D -induced myeloproliferative neoplasm

Systemic Notch downregulation promotes Kras^G12D -induced myeloproliferative neoplasm

Br J Haematol. 2019 Aug;186(3):e52-e56. doi: 10.1111/bjh.15893. Epub 2019 Mar 31.

Xiaona You¹, Zhi Wen¹, Yuan-I Chang^{1

2}, Erik A Ranheim³, Yun Zhou¹, Lan Zhou⁴, Guangyao Kong⁵, Jing Zhang¹

¹ McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA.
² Institute of Physiology, National Yang-Ming University, Taipei City, Taiwan.
³ Department of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
⁴ Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.
⁵ National Local Joint Engineering Research Centre of Biodiagnostics and Biotherapy, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R.China.

No abstract available

Keywords: NOTCH signalling; myeloproliferative neoplasm; oncogenic Kras.