Integrins and Their Role in Immune Cell Adhesion

Cell. 2019 Apr 18;177(3):499-501. doi: 10.1016/j.cell.2019.03.038. Epub 2019 Apr 2.

Abstract

One of the 2019 Canada Gairdner International Awards recognizes Timothy Springer's discovery of the first immune system adhesion molecules involved in lymphocyte homing and the translation of those discoveries into therapeutics for autoimmune disease and cancer.

Publication types

  • Review

MeSH terms

  • Actin Cytoskeleton
  • Antibodies, Monoclonal / immunology
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / therapy
  • Cell Adhesion / physiology*
  • Humans
  • Integrins / metabolism*
  • Membrane Glycoproteins / metabolism
  • Neoplasms / immunology
  • Neoplasms / therapy
  • P-Selectin / metabolism
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism*

Substances

  • Antibodies, Monoclonal
  • Integrins
  • Membrane Glycoproteins
  • P-Selectin
  • P-selectin ligand protein